Sia Analiz
Systemic Toxicity
Within the scope of biological risk assessment of medical devices, acute, subacute, subchronic, and chronic systemic toxic effects that may be caused by medical devices are evaluated by applying single and repeated doses of polar and/or apolar extracts obtained from medical devices. In this context, systemic toxicity is evaluated, including parenteral applications or implantation of medical devices. Clinical, necropsy, histopathology, hematology, and biochemical parameters are used in this evaluation. Systemic toxicity is carried out by the principles specified in the ISO 10993-11 standard. For this purpose, animal species (Rat, Mouse, etc.) mentioned in the standard are used.
